The clinical similarity among different neuropsychiatric disorders (NPDs) suggested a shared genetic basis. We catalogued 23,109 coding de novo mutations (DNMs) from 6511 patients with autism spectrum disorder (ASD), 4,293 undiagnosed developmental disorder (UDD), 933 epileptic encephalopathy (EE), 1022 intellectual disability (ID), 1094…

Recent meta-analytic work has highlighted lower creativity in schizophrenic patients as compared to control participants, but the cognitive and affective underpinnings of this difference still need to be fully understood. To this purpose, we adopted a multi-measure approach and compared a group of schizophrenic outpatients and a group of…

Assessment of schizophrenia (SCZ) in people with autism spectrum disorder (ASD) is complicated due to confounding symptoms between ASD and SCZ. These confounding factors are aggravated when the patient has sparse verbal skills. A selective review was conducted to identify behavioural equivalents when assessing SCZ in individuals with ASD with…

Background: Patients with schizophrenia present with both cognitive impairment as well as language difficulties. There are similarities in the language output of patients with schizophrenia and patients with aphasia, thus a differential diagnosis of patients who present with a question of dual diagnoses can be a clinical challenge. This case…

Autism (ASD) and schizophrenia spectrum disorders (SCZ) are neurodevelopmental conditions with overlapping and interrelated symptoms. A network analysis approach that represents clinical conditions as a set of "nodes" (symptoms) connected by "edges" (relations among symptoms) was used to compare symptom organization in the two…

Medication noncompliance is a significant challenge in managing schizophrenia, a chronic and severe mental health disorder characterized by symptoms such as delusions, hallucinations, disorganized thinking, and impaired functioning. Schizophrenia presents both positive symptoms, which involve exaggerated thoughts or behaviors, and negative…

Introduction: Mental health assessment in autistic individuals with intellectual disabilities may be challenging. Findings from non-autistic samples indicate overlap between obsessive-compulsive disorder (OCD) and psychotic disorder/schizophrenia, but little is known about this potential overlap in autistic people. Methods: Explorative,…

Positive implications of schizotypal personality have been discussed in the literature in the last few years, higher creativity being one of them. Specifically, positive and negative schizotypy dimensions have been respectively related to higher and lower creativity levels. However, a considerable amount of null associations between these two…

Background: The frequency and intensity of physical activity are directly related to health in the general population. However, to our knowledge, no study has looked at that relationship in people with intellectual disability. Method: The aim of this study was to determine whether there were differences in the health of 407 people with…

Few studies have compared knowledge of the specific health risks of cannabis across jurisdictions. This study aimed to examine perceptions of the health risks of cannabis in Canada and US states with and without legal non-medical cannabis. Cross-sectional data were collected from the 2018 and 2019 International Cannabis Policy Study online…

Background: Positive symptoms of schizophrenia are associated with significant difficulties in daily functioning, and these difficulties have been associated with impaired executive functions (EEFF). However, specific cognitive and socio-emotional executive deficits have not been fully established. Objective: The present study has several…

We examined the basis of feeling-of-knowing judgments (FOK) in patients with schizophrenia. Such patients typically have impaired memory and awareness, but not metamemory-accuracy deficits. The magnitude of FOKs are lower for patients with schizophrenia than for healthy participants, but judgments equally predict memory performance. In healthy…

Devoted to the late Paul Virilio (1932-2018) and in the advent of debates surrounding the Anthropocene and in light of corresponding changes to conceptions of scale and image, this paper attempts to extrapolate a Virilian pedagogy of the image. It is Virilio's work which remains timely and singularly fecund in this area and it is for this reason…

A series of recent papers has demonstrated "mirror extreme" variation in measures of brain size, between individuals with deletions compared to duplications, for copy number variation loci. For most loci, ASD-associated CNVs involve larger brain sizes, and schizophrenia-associated CNVs involve smaller brain sizes, the same patterns also…

Previous research has attempted to understand why countries with relatively favorable conditions and high estimated average IQs (such as Finland and Japan) have a relatively low per capita number of scientific Nobel prizes. In the present study, we examine whether there is a relationship between national schizophrenia and left-handedness…