The University of Lagos is one of Nigeria's premiere Universities, established in 1962 with core values emphasizing commitment to quality academic learning and character, integrity, continuous improvement of staff professionalism and competence, as well as a strong commitment to cutting-edge research. In 2012, the University established the Research and Innovation Office, which was subsequently restructured into two offices: the Research Management Office, and the Innovation and Technology Transfer Office, for more efficient functioning. Over the years, the Office has provided enormous support to over 1,700 academic faculty and researchers for cutting-edge research built on a multi-disciplinary approach. This paper provides a detailed discussion of the strategies employed by the Research Management Office to promote multi-disciplinary research from inception to date, the results of efforts to promote collaboration across the currently existing wealth of diversity in academic and research disciplines among researchers in over 12 faculties of the University, the successes recorded, and the challenges faced. The paper further makes recommendations for the advancement of these strategies, and suggestions for pragmatic solutions to challenges experienced while drawing practical and applicable lessons from international best practices for supporting multi-disciplinary research.