We examine the effects of interviewer-respondent familiarity on both response patterns and rates of item nonresponse when self-administered questions (SAQs) are used. We use SAQ data from a survey in which the researchers experimentally ensured that there would be varying degrees of familiarity between interviewers and respondents. Our results reveal only minimal differences in response patterns by degree of prior acquaintance between interviewer and respondent, indicating that SAQs are effective at eliminating potential bias stemming from such relationships. Our results for item nonresponse depend on how we measure the relationship between interviewer and respondent; but in all cases, it is clear that prior knowledge of one another, far from harmful, leads to low nonresponse rates to SAQs. Thus, researchers using SAQs may not need to adhere to the norm that interviewers and respondents must be strangers, with practical and cost-effective consequences for data collection.