Researchers and policy makers have proposed that quality of life (QOL) is an important and useful way to measure the impact of services, although practical application of QOL in rehabilitation has been limited. In this study, a comprehensive framework (the International Classification of Functioning [ICF]) is used to compare the relationship between QOL and function in key life areas in a sample of adults with disabilities receiving vocational services (n = 224). Results of a multiple regression analysis indicated that level of education, duration of disability, difficulty with social relationships and inclusion, the impact of the disability or health condition on the person or his or her family, and relational support and attitudes of family, friends, and acquaintances showed significant relationships with QOL. This study highlights the role of the social impact of disability on QOL and provides support for the use of the ICF for conceptualizing disability and its impact in a way that is inclusive of personal and environmental factors.