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The Heavy Burden of Psychiatric Comorbidity in Youth with Autism Spectrum Disorders: A Large Comparative Study of a Psychiatrically Referred Population
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Joshi, Gagan; Petty, Carter; Wozniak, Janet; Henin, Aude; Fried, Ronna; Galdo, Maribel; Kotarski, Meghan; Walls, Sarah; Biederman, Joseph – Journal of Autism and Developmental Disorders, 2010
The objective of the study was to systematically examine patterns of psychiatric comorbidity in referred youth with autism spectrum disorders (ASD) including autistic disorder and pervasive developmental disorder not otherwise specified. Consecutively referred children and adolescents to a pediatric psychopharmacology program were assessed with…
Descriptors: Autism, Pharmacology, Pervasive Developmental Disorders, Comparative Analysis
The CBCL Bipolar Profile and Attention, Mood, and Behavior Dysregulation
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Doerfler, Leonard A.; Connor, Daniel F.; Toscano, Peter F. – Journal of Child and Family Studies, 2011
Biederman and colleagues reported that a CBCL profile identified youngsters who were diagnosed with bipolar disorder. Some studies found that this CBCL profile does not reliably identify children who present with bipolar disorder, but nonetheless this CBCL does identify youngsters with severe dysfunction. However, the nature of the impairment of…
Descriptors: Aggression, Psychiatry, Pharmacology, Profiles
The Child and Adolescent Psychiatry Trials Network
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March, John S.; Silva, Susan G.; Compton, Scott; Anthony, Ginger; DeVeaugh-Geiss, Joseph; Califf, Robert; Krishnan, Ranga – Journal of the American Academy of Child and Adolescent Psychiatry, 2004
Objective: The current generation of clinical trials in pediatric psychiatry often fails to maximize clinical utility for practicing clinicians, thereby diluting its impact. Method: To attain maximum clinical relevance and acceptability, the Child and Adolescent Psychiatry Trials Network (CAPTN) will transport to pediatric psychiatry the practical…
Descriptors: Psychiatry, Pharmacology, Patients, Pediatrics
Multiple-Dose Pharmacokinetics of Fluvoxamine in Children and Adolescents.
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Labellarte, Michael; Biederman, Joseph; Emslie, Graham; Ferguson, James; Khan, Arifulla; Ruckle, Jon; Sallee, Randy; Riddle, Mark – Journal of the American Academy of Child and Adolescent Psychiatry, 2004
Objective: To determine the pharmacokinetics of fluvoxamine in children and adolescents and to compare pharmacokinetic data from adolescents to adults from a previous study. Method: Fluvoxamine was titrated to a target dose of 100 mg b.i.d. in children (6-11 years) and 150 mg b.i.d. in adolescents (12-17 years) with obsessive-compulsive disorder…
Descriptors: Psychiatry, Pharmacology, Females, Adolescents
The Treatment for Adolescents with Depression Study (TADS): Demographic and Clinical Characteristics
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n/a; n/a – Journal of the American Academy of Child and Adolescent Psychiatry, 2005
Objective: The Treatment for Adolescents With Depression Study is a multicenter, randomized clinical trial sponsored by the NIMH. This study is designed to evaluate the short- and long-term effectiveness of four treatments for adolescents with major depressive disorder: fluoxetine, cognitive-behavioral therapy, their combination, and, acutely,…
Descriptors: Psychiatry, Psychopathology, Pharmacology, Adolescents
Aacap 2002 Research Forum: Placebo and Alternatives to Placebo in Randomized Controlled Trials in Pediatric Psychopharmacology
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March, John; Kratochvil, Christopher; Clarke, Gregory; Beardslee, William; Derivan, Albert; Emslie, Graham; Green, Evelyn P.; Heiligenstein, John; Hinshaw, Stephen; Hoagwood, Kimberly; Jensen, Peter; Lavori, Philip; Leonard, Henrietta; McNulty, James; Michaels, M. Alex; Mossholder, Andrew; Osher, Trina; Petti, Theodore; Prentice, Ernest; Vitiello, Benedetto; Wells, Karen – Journal of the American Academy of Child and Adolescent Psychiatry, 2004
Objective: The use of placebo in the pediatric age group has come under increasing scrutiny. At the 2002 Annual Meeting of the American Academy of Child and Adolescent Psychiatry, the Academy's Workgroup on Research conducted a research forum. The purpose was to identify challenges and their solutions regarding the use of placebo in randomized…
Descriptors: Research Design, Psychiatry, Pharmacology, Industry
Hormonal Correlates of Clozapine-Induced Weight Gain in Psychotic Children: An Exploratory Study
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Sporn, Alexandra L.; Bobb, Aaron J.; Gogtay, Nitin; Stevens, Hanna; Greenstein, Deanna K.; Clasen, Liv S.; Tossell, Julia W.; Nugent, Thomas; Gochman, Peter A.; Sharp, Wendy S.; Mattai, Anand; Lenane, Marge C.; Yanovski, Jack A.; Rapoport, Judith L. – Journal of the American Academy of Child and Adolescent Psychiatry, 2005
Objective: Weight gain is a serious side effect of atypical antipsychotics, especially in childhood. In this study, the authors examined six weight gain-related hormones in patients with childhood-onset schizophrenia (COS) after 6 weeks of clozapine treatment. Method: Fasting serum samples for 24 patients with COS and 21 matched healthy controls…
Descriptors: Psychiatry, Patients, Schizophrenia, Obesity
The Handbook of Psychiatric Drug Therapy for Children and Adolescents.
Theesen, Karen A. – 1995
A compilation of literature and clinical wisdom, this handbook provides the reader with current information on the safety and efficacy of the psychotropic agents in the pediatric population. It lists information on the pharmacokinetics, adverse effects, dosing, and suggested monitoring guidelines for children and adolescents. The guide may also be…
Descriptors: Adolescents, Children, Drug Therapy, Elementary Secondary Education
Case Study: Severe Self-Injurious Behavior in Comorbid Tourette's Disorder and OCD
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Hood, Korey K.; Baptista-Neto, Lourival; Beasley, Pamela J.; Lobis, Robert; Pravdova, Iva – Journal of the American Academy of Child and Adolescent Psychiatry, 2004
This case report describes the successful treatment of severe self-injurious behavior in a 16-year-old adolescent with Tourette's disorder and obsessive-compulsive disorder. Treatment is described from initial presentation to the emergency department for severe self-inflicted oral lacerations through discharge from the inpatient psychiatric…
Descriptors: Psychiatry, Psychiatric Services, Pharmacology, Psychological Services
Child and Adolescent Psychopharmacology in the New Millennium: A Workshop for Academia, Industry, and Government
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Deveaugh-Geiss, Joseph; March, John; Shapiro, Mark; Andreason, Paul J.; Emslie, Graham; Ford, Lisa M.; Greenhill, Laurence; Murphy, Dianne; Prentice, Ernest; Roberts, Rosemary; Silva, Susan; Swanson, James M.; van Zwieten-Boot, Barbara; Vitiello, Benedetto; Wagner, Karen Dineen; Mangum, Barry – Journal of the American Academy of Child and Adolescent Psychiatry, 2006
Objective: To give academic researchers, government officials, and industry scientists an opportunity to assess the state of pediatric psychopharmacology and identify challenges facing professionals in the field. Method: Increased federal spending and the introduction of pediatric exclusivity led to large increases in pediatric psychopharmacology…
Descriptors: Safety, Psychiatry, Mental Disorders, Research Needs
A Feasibility Study of the Childhood Depression Medication Algorithm: The Texas Children's Medication Algorithm Project (Cmap)
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Emslie, Graham J.; Hughes, Carroll W.; Crismon, M. Lynn; Lopez, Molly; Pliszka, Steve; Toprac, Marcia G.; Boemer, Christine – Journal of the American Academy of Child and Adolescent Psychiatry, 2004
Objective: To evaluate the feasibility and impact on clinical response and function associated with the use of an algorithm-driven disease management program (ALGO) for children and adolescents treated for depression with or without attention-deficit/hyperactivity disorder (ADHD) in community mental health centers. Method: Interventions included…
Descriptors: Outcomes of Treatment, Severity (of Disability), Measures (Individuals), Psychiatry
Treatment for Adolescents with Depression Study (TADS): Safety Results
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Emslie, Graham; Kratochvil, Christopher; Vitiello, Benedetto; Silva, Susan; Mayes, Taryn; McNulty, Steven; Weller, Elizabeth; Waslick, Bruce; Casat, Charles; Walkup, John; Pathak, Sanjeev; Rohde, Paul; Posner, Kelly; March, John – Journal of the American Academy of Child and Adolescent Psychiatry, 2006
Objective: To compare the rates of physical, psychiatric, and suicide-related events in adolescents with MDD treated with fluoxetine alone (FLX), cognitive-behavioral therapy (CBT), combination treatment (COMB), or placebo (PBO). Method: Safety assessments included adverse events (AEs) collected by spontaneous report, as well as systematic…
Descriptors: Safety, Patients, Adolescents, Suicide