Maker-centered learning is a creative hands-on educational strategy that uses a variety of tools and materials to support the iterative design of physical or digital artifacts. It involves the "messy" process of trial and error; therefore, authentic integration of maker-centered learning requires teachers to embrace ambiguity. This descriptive case study explores how two in-service teacher participants tolerate ambiguity through unpacking the ways that they process, interpret, and react to ambiguous stimuli. The study uses participants' weekly reflections during a 15-week course focused on tools and strategies to support maker-centered learning. Findings highlight examples of how participants' experiences connect to the four ambiguity constructs (i.e., complexity, insolubility, uncertainty, unfamiliarity) and the dual roles of ambiguity as a learner and ambiguity as a teacher. Implications for teacher educators who design maker-centered learning professional development experiences are also discussed.