We live in a world and a time full of challenges. Social inequality, discrimination, global political instability, wars, genocides, terrorism, nuclear and biological weapons, climate change, waste disposal, and species extinction, among others, are constant threats. These pressing issues require attention and solution. Wisdom rises as the overarching construct to holistically address complex human phenomena. Using the Polyhedron Model of Wisdom as a framework to analyze crises, the authors address the current COVID-19 pandemic. People's and leaders' reactions to the crisis are evaluated using seven Wisdom components: knowledge, intelligence, creativity, self-regulation, openness and tolerance, altruism and moral maturity, and sound judgment. Implications of the implementation and promotion of wisdom for ethical problem-solving are discussed.