Objective: This study examined whether studying in a Consciousness-Based Education institution influenced college students' mental and physical health. Participants and methods: Undergraduate college students (n = 321) completed the Duke Health Profile, assessing 11 areas of mental and physical health, both as entering freshmen (2008-2014) and at graduation. The archived data was analyzed from 2019 to 2020. Results: Using ANOVA for all 11 subscales revealed significant increases in physical, mental, and general health, self-esteem (P < 0.001), perceived health (P < 0.017); and significant decreases in anxiety, depression, and anxiety-depression (P < 0.001). There were no significant group effects on pain, disability, or social health. Conclusions: Consciousness-Based Education was found to buffer the effects of stress on mental and physical health in college students. Consciousness-Based Education's influence in lowering anxiety and depression while improving self-esteem and general health presents an effective tool for educators and administrators to consider in assisting students combating the stress of college life.