Since the 1990s the number of children with disabilities placed within the general education classroom has steadily increased. Many of these children are provided special education services under the generic disability title "intellectual disability." Over the past decade, there has been a significant amount of research concerning rare genetic syndromes that result in separating developmental disabilities into categories using similar origins and characteristics. Costello syndrome is one of these rare syndromes. Although information is available to medical practitioners, it has seldom been communicated to educators. The authors have taken the available data and, using a team approach, made recommendations for involving medical and health professionals in educating students with Costello syndrome.