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Johnson, Alan T. – Journal of Chemical Education, 2015
At present, small molecule drug design follows a retrospective path when considering what analogs are to be made around a current hit or lead molecule with the focus often on identifying a compound with higher intrinsic potency. What this approach overlooks is the simultaneous need to also improve the physicochemical (PC) and pharmacokinetic (PK)…
Descriptors: Molecular Structure, Science Instruction, Chemistry, Pharmacology