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Kelly-Hunt, Alexandra E.; Mehan, Aman; Brooks, Sarah; Leanca, Miron A.; McKay, Jack E. D.; Mahamed, Nashad; Lambert, Daniel; Dempster, Nicola M.; Allen, Robert J.; Evans, Andrew R.; Sarker, Satyajit D.; Nahar, Lutfun; Sharples, George P.; Drew, Michael G. B.; Fielding, Alistair J.; Ismail, Fyaz M. D. – Journal of Chemical Education, 2022
Purpurogallin (PPG), an orange-red crystalline compound from nutgalls and oak bark, is an exemplar of numerous, ubiquitous natural colorants, biosynthesized through oxidative dimerization-decarboxylation of phenolic compounds. It possesses antioxidant, anticancer, and anti-inflammatory effects. Herein, a robust method is presented to allow…
Descriptors: Science Instruction, Spectroscopy, Science History, Pharmacology
Mo´nica I. Garci´a-Aranda; Marco Franco-Pe´rez; Angel Zamudio-Medina – Journal of Chemical Education, 2023
Heterocyclic compounds are an integral part of research, particularly in the pharmaceutical field. The synthesis of such compounds in an undergraduate laboratory can help students understand the relevance and importance of their field of study. Our experimental activity introduces a novel procedure to synthesize coumarin, a heterocyclic formed by…
Descriptors: Undergraduate Students, College Science, Chemistry, Laboratory Experiments
Carmen Velez; Kristie Cheng; Sabrina Woodward; Noor Nazeer; Gabriela Nicole Hislop Gomez; Cody O. Crosby – Journal of Chemical Education, 2024
Many undergraduate chemistry and biochemistry students pursue careers in healthcare. Biomaterials, designed to harmonize with the complexity of the human body, have become increasingly significant in medicine as implants, drug delivery vehicles and tissue scaffolds. We believe it is essential that undergraduates are exposed to biomaterial…
Descriptors: Chemistry, Scientific Concepts, Medicine, College Science
Fu, Wei; Li, Wei; Chen, Boyu; Zhang, Junjie; Xie, Qiong; Zhou, Lu; Zhang, Xuemei – Biochemistry and Molecular Biology Education, 2023
With the emergence of innovative technologies, including combinatorial chemistry, high-throughput screening, computer-aided drug design (CADD), artificial intelligence (AI) and big data, the importance of drug design in the field of drug discovery and development is increasing. Additionally, education in drug design plays an important role in the…
Descriptors: Chemistry, Pharmaceutical Education, Computer Assisted Design, Artificial Intelligence
Jiro Kondo; Shota Nakamura – Journal of Chemical Education, 2023
The use of molecular models in chemistry and biochemistry classes is very effective in helping students understand covalent bonds and the chemical structure of molecules. However, conventional molecular models cannot represent intermolecular interactions such as hydrogen bonds and electrostatic interactions. Herein, we describe 3D printed…
Descriptors: Chemistry, Molecular Structure, Scientific Concepts, Biochemistry
Mohamed Touaibia; Natalie A. Levesque – Journal of Chemical Education, 2024
Heterocycles, more specifically those containing nitrogen, make up a family of molecules with great pharmaceutical potential. Many approved drugs, notably anticancer drugs, contain a nitrogen-based heterocycle. To expose students to this class of molecules, we used the Paal--Knorr reaction for the synthesis of edaravone, a pyrazolone derivative.…
Descriptors: Chemistry, College Science, Undergraduate Students, Undergraduate Study
Audrey G. Fikes; Melissa C. Srougi – Journal of Chemical Education, 2023
The application of chemistry concepts in biological settings plays an important role in the interdisciplinary field of drug discovery and development. This is true for molecular docking, where an understanding of intermolecular forces and noncovalent interactions is useful for rational drug design and development. Here we report the design and use…
Descriptors: Chemistry, Science Instruction, Molecular Structure, Drug Therapy
Milicaj, Jozafina; Dodda, Vasudeva R.; Patel, Kaelan R.; Aragon, Ingrid Rodriguez; O'Connell, Timothy; Muthyala, Ramaiah; Taylor, Erika A.; Sham, Yuk Y. – Journal of Chemical Education, 2022
Research has shown that the use of practical examples in undergraduate education promotes the retention of historically underrepresented students in STEM majors and lowers achievement gaps within courses. Since many students of color and women aspire toward careers in healthcare and the pharmaceutical industry, efforts to incorporate medicinal…
Descriptors: College Science, Chemistry, Medicine, Undergraduate Study
Joana F. C. Silva; Ma´rio T. S. Rosado; Teresa M. R. Maria; Pedro S. Pereira Silva; Manuela Ramos Silva; M. Ermelinda S. Euse´bio – Journal of Chemical Education, 2023
The concept of co-amorphous systems is introduced in an integrated laboratory experiment, designed for advanced chemistry students, using solvent-free, environmentally friendly mechanochemistry. The dual-drug naproxen-cimetidine co-amorphous system (NPX-CIM) is investigated as an example of the emergent field of medicinal mechanochemistry.…
Descriptors: Laboratory Experiments, Chemistry, Science Instruction, Pharmacology
Aisha Alsfouk – Journal of Chemical Education, 2023
Fourth- and fifth-year pharmacy students attending integrated pharmacotherapy courses at Princess Nourah bint Abdulrahman University completed a medicinal chemistry assignment using computer-based technology. This written assignment encompassed multiple components requiring the use of free online resources to study and illustrate several stages of…
Descriptors: Undergraduate Students, Pharmaceutical Education, Medicine, Chemistry
Elizabeth W. Kelley – Journal of Chemical Education, 2023
The pharmaceutical industry has been a major player in improving life expectancies and driving chemistry employment. While computational chemistry tools increasingly guide pharmaceutical research decisions, high school and undergraduate chemistry curricula do not reflect the prevalence of such techniques. Incorporation of computational tools into…
Descriptors: Secondary School Science, High School Students, Chemistry, Computer Assisted Design
Shannon C. Timmons; Aleksandra Kuzmanov – Journal of Chemical Education, 2024
Health-related career goals are popular among high school science students, yet few understand the application of chemistry and biology research to the field of medicine and its impact on society. In this five-day multidisciplinary summer camp, high school students learn about the real-world relevance of medicinal chemistry research and its…
Descriptors: Scientific Concepts, Molecular Structure, Medicine, Interdisciplinary Approach
Roach, Jimmy D.; Nauman, Areej; Mahmud, Shamin; Chaari, Ali; Bondaruk, Mandy – Biochemistry and Molecular Biology Education, 2022
Research experience is becoming an increasingly crucial element of today's undergraduate science curriculum. In recent years, the establishment of the Course-Based Undergraduate Research Experience Network (CUREnet) has provided a framework for the development of courses aiming to cultivate students' proficiency in undergraduate research…
Descriptors: Undergraduate Study, College Science, Science Instruction, Science Laboratories
Wanmei Li; Yani Ouyang; Jun Xu; Pengfei Zhang – Journal of Chemical Education, 2022
Medicinal chemistry, as the core curriculum of the pharmaceutical engineering major, contains complex knowledge systems and scattered knowledge points. A medicinal chemistry course covers more than 50kinds of drugs divided into 11 categories including antibiotics, antiparasitic drugs, anesthetics, nonsteroidal anti-inflammatory drugs, and nervous…
Descriptors: Student Centered Learning, Cooperative Learning, Teamwork, Science Instruction
Bodek, Matthew; Burch, Mary; Cannon, Joshua; Finneran, David; Geveke, Kathleen; Sinkinson, Heather; Smith, William; Tierney, John – Journal of Chemical Education, 2020
The spectrophotometric determination of the percent composition of an aspirin tablet is a common first-year, general chemistry undergraduate laboratory procedure. The experiment requires that a known amount of pure acetylsalicylic acid be quantitatively converted into the soluble disodium salicylic acid that is further reacted with excess…
Descriptors: Chemistry, Spectroscopy, Laboratory Experiments, Hands on Science