At present, small molecule drug design follows a retrospective path when considering what analogs are to be made around a current hit or lead molecule with the focus often on identifying a compound with higher intrinsic potency. What this approach overlooks is the simultaneous need to also improve the physicochemical (PC) and pharmacokinetic (PK)…

Most introductory physics courses include a chapter on "RC" circuits in which the differential equations for the charging and discharging of a capacitor are derived. A number of papers in this journal describe lab experiments dealing with the measurement of different parameters in such "RC" circuits. In this contribution, we…

High-resolution solid-state NMR (SSNMR) spectroscopy has many advantages as a tool to characterize solid-phase material that finds applications in polymer chemistry, nanotechnology, materials science, biomolecular structure determination, and others, including the pharmaceutical industry. The technology associated with achieving high resolution…

Human beings vary in their responses to the drugs prescribed to them. These variations can be due to differences in their age, gender, weight, health status, diet, concurrent therapy and genetic make-up. Recently, it has been estimated that 85% of a patient's response to drugs is due to the genetic make-up of the individual (Snedden, 1999).…

A lecture given in courses in applied pharmacokinetics at Wayne State University, Michigan, is presented. The definition of bioavailability is reviewed along with methods of calculation, bioequivalence, criteria for establishing bioequivalence of a new product, essentials of a bioequivalence study, and the relationship between bioequivalence and…

Recent advances in the development of radionuclide labeled monoclonal antibodies as radiopharmaceuticals should result in commercially available products in the near future. This presentation describes mechanisms by which radiation can destroy cells, factors influencing the potential for successful treatment, concepts to understanding the use of…

To provide graduate students in pharmacology/toxicology exposure to, and cross-training in, a variety of relevant laboratory skills, the Duquesne University School of Pharmacy developed a "methods" course as part of the core curriculum. Because some of the participating departmental faculty are neuroscientists, this course often applied…

A course developed to fill a gap related to women's health issues in the University of Georgia's pharmacy curriculum is described. Specific discussion topics include pregnancy, obstetrics analgesic, drugs in breast milk, endometriosis, dysmenorrhea, and infertility. Course objectives and a course outline are appended. (Author/MLW)

Program objectives of a drug information rotation at the Upjohn Company include improving communication between the pharmaceutical industry and hospital pharmacy/academia, exposing the resident to the challenges the industry encounters, improving proficiency in drug information practice, and providing insight into the working relationships of…

Describes a course provided for health profession-oriented students. Uses a chemical basis to explain the physiology of drug action while considering appropriate patient care. Outlines course content and testing procedures. (Author)

In a summer faculty development workshop, seven faculty in different pharmacy disciplines (biochemistry, therapeutics, pharmacy management, pharmaceutics, pathophysiology, pharmaceutical analysis, pharmacy administration) clarified critical thinking objectives for their courses, practiced this approach in a faculty workshop, and piloted the…

New standards of practice that describe in generic terms what a pharmacist does in fulfilling the basic responsibilities of the profession are presented as part of the Continuing Competence in Pharmacy Project of the American Pharmacy Association and the American Association of Colleges of Pharmacy. The four major areas of responsibilities for…