This study aims to investigate Vietnamese pain terms and pain descriptors with a focus on how the McGill Pain Questionnaire (MPQ) words are utilised by the Vietnamese patients. Semi-structured interviews were employed to collect data from twenty-six Vietnamese female cancer patients. The data were analysed using both quantitative and qualitative content analysis. The findings indicated that dau (hurt), nh?c (ache), and dau-nh?c (hurt and ache) are three basic pain terms in Vietnamese, with dau being a super-ordinate pain term. In addition, Vietnamese pain descriptors can be systematically classified into MPQ-VN descriptors and Non-MPQ-VN descriptors, with the latter being used far more frequently than the former. The study also found that MPQ descriptors could not reflect the patients' pain experience comprehensively in the Vietnamese context although the Vietnamese employed the equivalents of MPQ descriptors of different categories. That the limitations of Melzack's (1975) inventory of MPQ descriptors have been validated in Vietnamese has contributed to Vietnamese healthcare professionals' understanding of how the patients communicate about their pain experience using language. The study has also shed lights on applied linguists' research directions which can be extended to areas beyond language education, such as health, therapy, and counselling.