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Douaud, Gwenaelle; Mackay, Clare; Andersson, Jesper; James, Susan; Quested, Digby; Ray, Manaan Kar; Connell, Julie; Roberts, Neil; Crow, Timothy J.; Matthews, Paul M.; Smith, Stephen; James, Anthony – Brain, 2009
Early-onset schizophrenia appears to be clinically more severe than the adult-onset form of the disease. In a previous study, we showed that anatomically related grey and white matter abnormalities found in adolescents patients were larger and more widespread than what had been reported in the literature on adult schizophrenia. Particularly, we…
Descriptors: Control Groups, Schizophrenia, Autism, Legislators
Polli, Frida E.; Barton, Jason J. S.; Thakkar, Katharine N.; Greve, Douglas N.; Goff, Donald C.; Rauch, Scott L.; Manoach, Dara S. – Brain, 2008
To perform well on any challenging task, it is necessary to evaluate your performance so that you can learn from errors. Recent theoretical and experimental work suggests that the neural sequellae of error commission in a dorsal anterior cingulate circuit index a type of contingency- or reinforcement-based learning, while activation in a rostral…
Descriptors: Control Groups, Schizophrenia, Cognitive Processes, Cognitive Mapping
Hyde, Thomas M.; Deep-Soboslay, Amy; Iglesias, Bianca; Callicott, Joseph H.; Gold, James M.; Meyer-Lindenberg, Andreas; Honea, Robyn A.; Bigelow, Llewellyn B.; Egan, Michael F.; Emsellem, Esther M.; Weinberger, Daniel R. – Brain, 2008
There is comparatively little information about premorbid maturational brain abnormalities in schizophrenia (SCZ). We investigated whether a history of childhood enuresis, a well-established marker of neurodevelopmental delay, is associated with SCZ and with measures of brain abnormalities also associated with SCZ. A Diagnostic and Statistical…
Descriptors: Siblings, Schizophrenia, Mental Disorders, Attention Deficit Disorders