This research aims to investigate the parallel mediating role of intolerance of uncertainty and positivity on the relationship between self-compassion and school burnout. Hypotheses were tested in a sample of 304 Turkish adolescents using mediation analysis). The research consists of data obtained during the lockdown caused by COVID-19 in Türkiye. School Burnout Inventory, Positivity Scale, Self-Compassion Scale Short Form, and Intolerance of Uncertainty Scale measurement tools were applied online. Data were analyzed using correlation and parallel mediation analysis (Hayes's PROCESS). The results showed that intolerance of uncertainty and positivity mediated the indirect effect of self-compassion on school burnout. Investigating both negative and positive psychological variables in explaining school burnout can support interventions and policies to be planned in the school environment.