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Direct linkLorna Wheaton; Dan Jackson; Sylwia Bujkiewicz – Research Synthesis Methods, 2024
During drug development, evidence can emerge to suggest a treatment is more effective in a specific patient subgroup. Whilst early trials may be conducted in biomarker-mixed populations, later trials are more likely to enroll biomarker-positive patients alone, thus leading to trials of the same treatment investigated in different populations. When…
Descriptors: Patients, Drug Therapy, Pharmacology, Outcomes of Treatment
Doody, Owen; Bailey, Maria E. – Journal of Intellectual Disabilities, 2019
Pain is a multidimensional and subjective experience, and an ideal pain management regime needs to be comprehensive, integrative and involve all relevant persons. Multimodal interventions may include pharmacological, physical, social, psychological and spiritual approaches in order to address pain management at a molecular, functional,…
Descriptors: Intervention, Pain, Intellectual Disability, Drug Therapy
Tan, Mei; Bowers, Megan; Thuma, Phil; Grigorenko, Elena L. – New Directions for Child and Adolescent Development, 2020
Efavirenz (EFV) is a well-known, effective anti-retroviral drug long used in first-line treatment for children and adults with HIV and HIV/AIDS. Due to its narrow window of effective concentrations, between 1 and 4 µg/mL, and neurological side effects at supratherapeutic levels, several investigations into the pharmacokinetics of the drug and its…
Descriptors: Drug Therapy, Outcomes of Treatment, Acquired Immunodeficiency Syndrome (AIDS), Neurology
Pedder, Hugo; Dias, Sofia; Bennetts, Margherita; Boucher, Martin; Welton, Nicky J. – Research Synthesis Methods, 2019
Background: Model-based meta-analysis (MBMA) is increasingly used to inform drug-development decisions by synthesising results from multiple studies to estimate treatment, dose-response, and time-course characteristics. Network meta-analysis (NMA) is used in Health Technology Appraisals for simultaneously comparing effects of multiple treatments,…
Descriptors: Meta Analysis, Guidelines, Drug Therapy, Decision Making
Holmes, Eileen M.; Leahy, Joy; Walsh, Cathal D.; White, Arthur; Donnan, Peter T.; Lamrock, Felicity – Research Synthesis Methods, 2019
Indirect treatment comparisons are useful to estimate relative treatment effects when head-to-head studies are not conducted. Statisticians at the National Centre for Pharmacoeconomics Ireland (NCPE) and Scottish Medicines Consortium (SMC) assess the clinical and cost-effectiveness of new medicines as part of multidisciplinary teams. We describe…
Descriptors: Decision Making, Drug Therapy, Comparative Analysis, Pharmacology
Scahill, Lawrence; Sukhodolsky, Denis G.; Anderberg, Emily; Dimitropoulos, Anastasia; Dziura, James; Aman, Michael G.; McCracken, James; Tierney, Elaine; Hallett, Victoria; Katz, Karol; Vitiello, Benedetto; McDougle, Christopher – Autism: The International Journal of Research and Practice, 2016
Repetitive behavior is a core feature of autism spectrum disorder. We used 8-week data from two federally funded, multi-site, randomized trials with risperidone conducted by the Research Units on Pediatric Psychopharmacology Autism Network to evaluate the sensitivity of the Children's Yale-Brown Obsessive Compulsive Scale modified for autism…
Descriptors: Autism, Pervasive Developmental Disorders, Scores, Networks
Singh, Nikita; Reece, John – Australian Educational and Developmental Psychologist, 2014
This meta-analysis aims to inform clinical practice of treatment strategies for adolescents with major depressive disorder (MDD). The efficacy of three empirically validated treatments was compared to determine the most effective treatment. These were: cognitive-behavioural therapy (CBT), selective serotonin reuptake inhibitor (SSRI)…
Descriptors: Psychotherapy, Pharmacology, Pharmaceutical Education, Meta Analysis
Singh, Nirbhay N.; Lancioni, Giulio E.; Manikam, Ramasamy; Winton, Alan S. W.; Singh, Ashvind N. A.; Singh, Judy; Singh, Angela D. A. – Research in Autism Spectrum Disorders, 2011
Some individuals with autism engage in physical aggression to an extent that interferes with not only their quality of life, but also that of their parents and siblings. Behavioral and psychopharmacological treatments have been the mainstay of treatments for aggression in children and adolescents with autism. We evaluated the effectiveness of a…
Descriptors: Siblings, Aggression, Autism, Quality of Life
Faraone, Stephen V.; Spencer, Thomas J.; Kollins, Scott H.; Glatt, Stephen J.; Goodman, David – Journal of Attention Disorders, 2012
Objective: To explore dose-response effects of lisdexamfetamine dimesylate (LDX) treatment for ADHD. Method: This was a 4-week, randomized, double-blinded, placebo-controlled, parallel-group, forced-dose titration study in adult participants, aged 18 to 55 years, meeting "Diagnostic and Statistical Manual of Mental Disorders" (4th ed., text rev.)…
Descriptors: Attention Deficit Disorders, Rating Scales, Severity (of Disability), Drug Therapy
Scahill, Lawrence; McCracken, James T.; Bearss, Karen; Robinson, Fay; Hollander, Eric; King, Bryan; Bregman, Joel; Sikich, Lin; Dukes, Kimberly; Sullivan, Lisa; Anagnostou, Evdokia; Donnelly, Craig; Kim, Young-Shin; Ritz, Louise; Hirtz, Deborah; Wagner, Ann – Journal of Autism and Developmental Disorders, 2012
The Studies to Advance Autism Research and Treatment Network conducted a randomized trial with citalopram in children with Pervasive developmental disorders (PDDs). We present the rationale, design and sample characteristics of the citalopram trial. Subjects (128 boys, 21 girls) had a mean age of 9.3 (plus or minus 3.12) years; 132 (88.6%) were…
Descriptors: Pharmacology, Drug Therapy, Pervasive Developmental Disorders, Autism
Pavuluri, Mani N.; Passarotti, Alessandra M.; Fitzgerald, Jacklynn M.; Wegbreit, Ezra; Sweeney, John A. – Journal of the American Academy of Child & Adolescent Psychiatry, 2012
Objective: The current study examined the impact of risperidone and divalproex on affective and working memory circuitry in patients with pediatric bipolar disorder (PBD). Method: This was a six-week, double-blind, randomized trial of risperidone plus placebo versus divalproex plus placebo for patients with mania (n = 21; 13.6 [plus or minus] 2.5…
Descriptors: Short Term Memory, Comparative Analysis, Drug Therapy, Brain Hemisphere Functions
Valkenburg, Abraham J.; van Dijk, Monique; de Klein, Annelies; van den Anker, Johannes N.; Tibboel, Dick – Developmental Disabilities Research Reviews, 2010
The primary focus of pain research in intellectually disabled individuals is still on pain assessment. Several observational pain assessment scales are available, each with its own characteristics, its own target group and its own validated use. Observational studies report differences in the treatment of intra- and postoperative pain of…
Descriptors: Pain, Down Syndrome, Mental Retardation, Outcomes of Treatment
Daughton, Joan M.; Kratochvil, Christopher J. – Journal of the American Academy of Child & Adolescent Psychiatry, 2009
The advantages, disadvantages, as well as helpful hints on when to use several drug therapies against attention deficit hyperactivity disorder are discussed. The drugs discussed are methylphenidate, atomoxetine, clonidine, and bupropion.
Descriptors: Attention Deficit Hyperactivity Disorder, Drug Therapy, Outcomes of Treatment, Pharmacology
Hughes, Shannon; Cohen, David – Social Work, 2010
The purpose of this integrative review is to facilitate social work practitioners' understanding of how psychotropic drug harms are assessed in clinical trials and to make specific suggestions for social workers' increased involvement in detecting drug harms in their clients. The authors undertook a comprehensive review of interdisciplinary…
Descriptors: Drug Therapy, Outcomes of Treatment, Social Work, Caseworkers
Download full textAnnie E. Casey Foundation, 2009
The guidelines and supporting rationale presented in this paper were developed from the October 2007 "Best Practices for Mental Health in Child Welfare Consensus Conference" sponsored by Casey Family Programs, the Annie E. Casey Foundation and the REACH Institute (REsource for Advancing Children's Health). The purpose of the conference was to…
Descriptors: Child Welfare, Guidelines, Mental Health, Clinical Experience
