A rapidly growing literature indicates that supportive social relationships are associated with better physical and mental health. However, this research further reveals that interaction with others may also be conflicted and unpleasant. The purpose of the current study was to evaluate negative interaction that arises within a social context that is important to many older Mexican Americans (i.e., negative interaction with a member of the clergy). Findings from a nationwide survey of older Mexican Americans indicate that more frequent interpersonal conflict with a member of the clergy is associated with less favorable self-rated health as well as more acute and chronic health conditions. However, these effects were observed among older Mexican American women but not among older Mexican American men. (Contains 1 table.)