The Cooperative Extension National Framework for Health and Wellness calls on Extension professionals to operate in new ways that will shape "the context in which people grow, learn, work, and play" and to practice multidisciplinary and collaborative approaches in communities. In this article, we present three cases in Oregon as examples of how Extension faculty at Oregon State University are working to improve population health in rural Oregon communities in alignment with the Cooperative Extension National Framework for Health and Wellness. These examples highlight the roles Extension faculty can play in such work as well as associated successes and challenges.