Linguists generally acknowledge that there exists an inevitable inter-relationship between different levels of linguistic analysis--phonetics, phonology, morphology, syntax and semantics. Various linguistic labels are used to describe such a link. In particular, there exists a bridge between the phonology and morphology of particular languages. The term "morphophonemics" is generally used to describe linguistic statements that can be made of the phonemic structure of morphemes and their effect on the grammatical content of languages. This paper basically attempts a morphophonemic analysis of inflectional morphemes of nouns in two structurally and historically distinct languages (English and Ibibio) in order to discover points of differences and similarities using the Contrastive Analysis (CA) model of investigation as its theoretical framework. The results indicate that the two languages are structurally different. For instance, Ibibio is agglutinative, tonal and analytic in nature while English is basically analytic and intonational. The paper, therefore, analyzes the problem that the Ibibio speaker of English is likely to encounter in the study of the English word structure. Again, based on its findings, the paper corroborates Greenberg's (1964) and Essien's (2003) classifications of African and Southern Nigerian languages respectively.