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Direct linkBaram, Tallie Z.; Donato, Flavio; Holmes, Gregory L. – Learning & Memory, 2019
Spatial memory, the aspect of memory involving encoding and retrieval of information regarding one's environment and spatial orientation, is a complex biological function incorporating multiple neuronal networks. Hippocampus-dependent spatial memory is not innate and emerges during development in both humans and rodents. In children,…
Descriptors: Memory, Spatial Ability, Cognitive Processes, Neurological Organization
Bok, Levinus A.; Halbertsma, Feico J..; Houterman, Saskia; Wevers, Ron A.; Vreeswijk, Charlotte; Jakobs, Cornelis; Struys, Eduard; van der Hoeven, Johan H.; Sival, Deborah A.; Willemsen, Michel A. – Developmental Medicine & Child Neurology, 2012
Aim: The long-term outcome of the Dutch pyridoxine-dependent epilepsy cohort and correlations between patient characteristics and follow-up data were retrospectively studied. Method: Fourteen patients recruited from a national reference laboratory were included (four males, 10 females, from 11 families; median age at assessment 6y; range 2y…
Descriptors: Epilepsy, Seizures, At Risk Persons, Cognitive Development
Ballantyne, Angela O.; Spilkin, Amy M.; Hesselink, John; Trauner, Doris A. – Brain, 2008
The developing brain has the capacity for a great deal of plasticity. A number of investigators have demonstrated that intellectual and language skills may be in the normal range in children following unilateral perinatal stroke. Questions have been raised, however, about whether these skills can be maintained at the same level as the brain…
Descriptors: Neurological Impairments, Seizures, Intelligence Quotient, Brain
Spencer-Smith, Megan; Leventer, Richard; Jacobs, Rani; De Luca, Cinzia; Anderson, Vicki – Developmental Medicine & Child Neurology, 2009
Aim: Subcortical band heterotopia (SBH) or "double cortex" is a malformation of cortical development resulting from impaired neuronal migration. So far, research has focused on the neurological, neuroimaging, and genetic correlates of SBH. More recently, clinical reports and small sample studies have documented neuropsychological dysfunction in…
Descriptors: Intelligence Quotient, Genetics, Short Term Memory, Cognitive Processes
Holmes, Gregory L. – Mental Retardation and Developmental Disabilities Research Reviews, 2004
Both clinical and laboratory studies demonstrate that seizures early in life can result in permanent behavioral abnormalities and enhance epileptogenicity. Understanding the critical periods of vulnerability of the developing nervous system to seizure-induced changes may provide insights into parallel or divergent processes in the development of…
Descriptors: Seizures, Etiology, Anatomy, Brain
Blume, Warren T. – Mental Retardation and Developmental Disabilities Research Reviews, 2004
Lennox-Gastaut (L-G) syndrome is an intractable generalized epilepsy of childhood onset, associated with spike waves at a slow rate and paroxysmal fast activity. These epileptiform discharge patterns are thought to reflect excessive neocortical excitability and arise from neuronal and synaptic features peculiar to the immature central nervous…
Descriptors: Seizures, Brain, Social Isolation, Cognitive Development
