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Direct linkRogers, Jack T.; Cahill, Catherine M. – Learning & Memory, 2020
A set of common-acting iron-responsive 5'untranslated region (5'UTR) motifs can fold into RNA stem loops that appear significant to the biology of cognitive declines of Parkinson's disease dementia (PDD), Lewy body dementia (LDD), and Alzheimer's disease (AD). Neurodegenerative diseases exhibit perturbations of iron homeostasis in defined brain…
Descriptors: Neurological Impairments, Dementia, Brain, Cognitive Processes
Ammassari-Teule, Martine – Learning & Memory, 2020
Largely inspired from clinical concepts like brain reserve, cognitive reserve, and neural compensation, here we review data showing how neural circuits reorganize in presymptomatic and early symptomatic hAPP mice to maintain memory intact. By informing on molecular alterations and compensatory adaptations which take place in the brain before mice…
Descriptors: Brain, Cognitive Processes, Neurological Organization, Animals
Nosofsky, Robert M.; Denton, Stephen E.; Zaki, Safa R.; Murphy-Knudsen, Anne F.; Unverzagt, Frederick W. – Journal of Experimental Psychology: Learning, Memory, and Cognition, 2012
Studies of incidental category learning support the hypothesis of an implicit prototype-extraction system that is distinct from explicit memory (Smith, 2008). In those studies, patients with explicit-memory impairments due to damage to the medial-temporal lobe performed normally in implicit categorization tasks (Bozoki, Grossman, & Smith, 2006;…
Descriptors: Alzheimers Disease, Classification, Patients, Short Term Memory
McKee, Ann C.; Stein, Thor D.; Nowinski, Christopher J.; Stern, Robert A.; Daneshvar, Daniel H.; Alvarez, Victor E.; Lee, Hyo-Soon; Hall, Garth; Wojtowicz, Sydney M.; Baugh, Christine M.; Riley, David O.; Kubilus, Caroline A.; Cormier, Kerry A.; Jacobs, Matthew A.; Martin, Brett R.; Abraham, Carmela R.; Ikezu, Tsuneya; Reichard, Robert Ross; Wolozin, Benjamin L.; Budson, Andrew E.; Goldstein, Lee E.; Kowall, Neil W.; Cantu, Robert C. – Brain, 2013
Chronic traumatic encephalopathy is a progressive tauopathy that occurs as a consequence of repetitive mild traumatic brain injury. We analysed post-mortem brains obtained from a cohort of 85 subjects with histories of repetitive mild traumatic brain injury and found evidence of chronic traumatic encephalopathy in 68 subjects: all males, ranging…
Descriptors: Neurological Impairments, Head Injuries, Chronic Illness, Brain
Herrera, C.; Chambon, C.; Michel, B. F.; Paban, V.; Alescio-Lautier, B. – Neuropsychologia, 2012
Considering the high risk for individuals with amnestic Mild Cognitive Impairment (A-MCI) to progress towards Alzheimer's disease (AD), we investigated the efficacy of a non-pharmacological intervention, that is, cognitive training that could reduce cognitive difficulties and delay the cognitive decline. For this, we evaluated the efficacy of a…
Descriptors: Control Groups, Investigations, Intervention, Alzheimers Disease
Kuczera, Tanja; Stilling, Roman Manuel; Hsia, Hung-En; Bahari-Javan, Sanaz; Irniger, Stefan; Nasmyth, Kim; Sananbenesi, Farahnaz; Fischer, Andre – Learning & Memory, 2011
Learning and memory processes critically involve the orchestrated regulation of de novo protein synthesis. On the other hand it has become clear that regulated protein degradation also plays a major role in neuronal plasticity and learning behavior. One of the key pathways mediating protein degradation is proteosomal protein destruction. The…
Descriptors: Animals, Posttraumatic Stress Disorder, Alzheimers Disease, Diseases
Sylvain-Roy, Stephanie; Bherer, Louis; Belleville, Sylvie – Brain and Cognition, 2010
Temporal preparation was assessed in 15 Alzheimer's disease (AD) patients, 20 persons with mild cognitive impairment (MCI) and 28 healthy older adults. Participants completed a simple reaction time task in which the preparatory interval duration varied randomly within two blocks (short versus long temporal window). Results indicated that AD and…
Descriptors: Intervals, Reaction Time, Alzheimers Disease, Brain
Vemuri, Prashanthi; Weigand, Stephen D.; Przybelski, Scott A.; Knopman, David S.; Smith, Glenn E.; Trojanowski, John Q.; Shaw, Leslie M.; Decarli, Charlie S.; Carmichael, Owen; Bernstein, Matt A.; Aisen, Paul S.; Weiner, Michael; Petersen, Ronald C.; Jack, Clifford R., Jr. – Brain, 2011
The objective of this study was to investigate how a measure of educational and occupational attainment, a component of cognitive reserve, modifies the relationship between biomarkers of pathology and cognition in Alzheimer's disease. The biomarkers evaluated quantified neurodegeneration via atrophy on magnetic resonance images, neuronal injury…
Descriptors: Alzheimers Disease, Reading Tests, Verbal Learning, Pathology
Wattmo, Carina; Wallin, Asa K.; Londos, Elisabet; Minthon, Lennart – Gerontologist, 2011
Purpose of the Study: To identify risk factors for early nursing home placement (NHP) in Alzheimer's disease (AD), focusing on the impact of longitudinal change in cognition, activities of daily living (ADL), service utilization, and cholinesterase inhibitor treatment (ChEI). Design and Methods: In an open, 3-year, prospective, multicenter study…
Descriptors: Alzheimers Disease, Rating Scales, Patients, Nursing Homes
Daumas, Stephanie; Sandin, Johan; Chen, Karen S.; Kobayashi, Dione; Tulloch, Jane; Martin, Stephen J.; Games, Dora; Morris, Richard G. M. – Learning & Memory, 2008
Two experiments were conducted to investigate the possibility of faster forgetting by PDAPP mice (a well-established model of Alzheimer's disease as reported by Games and colleagues in an earlier paper). Experiment 1, using mice aged 13-16 mo, confirmed the presence of a deficit in a spatial reference memory task in the water maze by hemizygous…
Descriptors: Animals, Alzheimers Disease, Cognitive Processes, Neurological Impairments
Anderson, Lynda A.; Day, Kristine L.; Beard, Renee L.; Reed, Peter S.; Wu, Bei – Gerontologist, 2009
The present review assesses the public's perceptions about cognitive health and Alzheimer's disease among adults in the United States. We searched the published literature and Internet, and contacted experts in the field to locate surveys assessing the public's perceptions about cognition. We found 10 eligible surveys and abstracted data…
Descriptors: Alzheimers Disease, Brain, Mental Health, Memory
Krinsky-McHale, Sharon J.; Devenny, Darlynne A.; Kittler, Phyllis; Silverman, Wayne – American Journal on Mental Retardation, 2008
Adults with Down syndrome and early stage Alzheimer's disease showed decline in their ability to selectively attend to stimuli in a multitrial cancellation task. They also showed variability in their performance over the test trials, whereas healthy participants showed stability. These changes in performance were observed approximately 2 years…
Descriptors: Alzheimers Disease, Dementia, Attention Span, Down Syndrome
Milman, Lisa H.; Holland, Audrey; Kaszniak, Alfred W.; D'Agostino, Jerry; Garrett, Merrill; Rapcsak, Steve – Journal of Speech, Language, and Hearing Research, 2008
Purpose: The Scales of Cognitive and Communicative Ability for Neurorehabilitation (SCCAN; L. Milman & A. Holland, 2007) was developed in the hospital setting to address changes in assessment practice. The SCCAN was designed to provide an overview of impairment and activity limitations across 8 cognitive scales (Speech Comprehension, Oral…
Descriptors: Speech Communication, Alzheimers Disease, Adaptive Testing, Construct Validity
Fernandez-Duque, Diego; Black, Sandra E. – Brain and Cognition, 2008
This study explored possible deficits in selective attention brought about by Dementia of Alzheimer Type (DAT). In three experiments, we tested patients with early DAT, healthy elderly, and young adults under low memory demands to assess perceptual filtering, conflict resolution, and set switching abilities. We found no evidence of impaired…
Descriptors: Dementia, Attention, Young Adults, Patients
Alescio-Lautier, B.; Michel, B. F.; Herrera, C.; Elahmadi, A.; Chambon, C.; Touzet, C.; Paban, V. – Neuropsychologia, 2007
It has been proposed that visual recognition memory and certain attentional mechanisms are impaired early in Alzheimer disease (AD). Little is known about visuospatial recognition memory in AD. The crucial role of the hippocampus on spatial memory and its damage in AD suggest that visuospatial recognition memory may also be impaired early. The aim…
Descriptors: Short Term Memory, Visual Perception, Spatial Ability, Attention
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