This article provides a process to carefully evaluate the suitability of a content domain for which diagnostic classification models (DCMs) could be applicable and then optimized steps for constructing a test blueprint for applying DCMs and a real-life example illustrating this process. The content domains were carefully evaluated using a set of defined criteria, which are purposely defined to improve the success rate of DCM implementation. Given the domain, the Q-matrix is determined by a simulation-based approach using correct classification rates as criteria. Finally, a physics test on the final Q-matrix was developed, administered, and analyzed by the author and the subject-matter experts (SMEs).