In this article we analyze the classic Hodgkin and Keynes 1955 paper describing investigations of the independence principle, with the expectation that there is much students and educators can learn from such exercises, most notably how the authors applied their diverse skill set to tackling the numerous obstacles that the study presented. The…

Understanding complex physiological processes is a cornerstone of medical education, and one such fundamental concept is the regulation of the glomerular filtration rate (GFR) by Starling forces. Therefore, developing a physiologically sound educational model to demonstrate these forces can significantly enhance the learning experience for…

The five papers published by Hodgkin and Huxley in 1952 are seminal works in the field of physiology, earning their authors the Nobel Prize in 1963 and ushering in the era of membrane biophysics. The papers present a considerable challenge to the novice student, but this has been partly allayed by recent publications that have updated the…

The digestive system (DS) is a fundamental topic in biological science teaching. However, the literature indicates that students have difficulties in learning about it. In the present work, we focus on how early childhood Pre-Service Teachers (PSTs) develop their understanding of the DS regarding the CMP (Components-Mechanisms-Phenomena) framework…

Most undergraduate students do not have practical experience working with model organisms despite having theoretical knowledge of their importance. This practical was developed to offer students experience working with three species of nematode, including "Caenorhabditis elegans." In the first task, students prepare slides of three…

Proteins are essential for cell function, and their biological performance depends on three-dimensional (3D) structures. Insulin is made up of 51 amino acids and is a critical hormone involved in glycaemia regulation. In basic education, concepts involving proteins (synthesis, structure, interactions, and function) are abstract and difficult for…

There is a considerable amount of research on the nature and effectiveness of modeling as applied to student learning in science. However, few studies have examined the role of students' epistemic uncertainty in modeling and how teachers collaborate with students to recognize and utilize it as a pedagogical resource to support productive struggle…

The purpose of this article is to describe a modeling sequence about the digestive system. "What happens in your body when you have lactose intolerance?" is the initial question that will guide the activities. Students will build a 3D plaster cast of the digestive system as part of a modeling cycle through which they are expected to…

We often say food and fuels "contain" energy. It is more accurate to say that energy is stored in the "fuel-oxygen system" generated during photosynthesis. It is definitely "not" stored in fuels or food (except for the very small amount of energy that can be obtained during anaerobic respiration). Aerobic respiration…

Multiple choice questions are traditionally expensive to produce. Recent advances in large language models (LLMs) have led to fine-tuned LLMs that generate questions competitive with human-authored questions. However, the relative capabilities of ChatGPT-family models have not yet been established for this task. We present a carefully-controlled…

The distribution of pulmonary blood flow is uneven and can be described as a three-zone model, the West zones: zone 1 occurs whenever alveolar pressure exceeds arterial pressure; zone 2 when the arterial pressure is greater than alveolar but the alveolar pressure exceeds the venous pressure; and finally zone 3 when both arterial and venous…

There remains a clear deficiency in recruiting middle school students in science, technology, engineering, mathematics, and medicine fields, especially for those students entering physiology from underrepresented backgrounds. A large part of this may be arising from a disconnect between how science is typically practiced at a collegiate and K-12…

Blood flow through the cardiovascular system is governed by the same physical rules that govern the flow of water through domestic plumbing. Using this analogy in a teaching laboratory, a model of the cardiovascular system constructed of pumps and pipes was used to demonstrate the basic interactions of pressure, flow, and resistance in a regulated…

For many reasons, physiological aspects of anatomy and physiology laboratories are often presented as simulations. While simulations effectively convey concepts, hands-on activities promote more active student engagement. Recycled soda bottles, supplemented with other inexpensive readily available supplies, can be used to create working models…

There remains a strong movement for Introductory Physics for Life Sciences (IPLS) courses to better integrate physics and biology. Part of the challenge for IPLS educators is to introduce fundamental physical law while simultaneously establishing the relevance of physics to biological science. Life science relevant laboratory experiences are…