G. T. Fechner (1860/1966) famously described two kinds of psychophysics: "Outer psychophysics" captures the black box relationship between sensory inputs and perceptual magnitudes, whereas "inner psychophysics" contains the neural transformations that Fechner's outer psychophysics elided. The relationship between the two has never been clear.…

We examined the organization and function of the ventral object processing pathway. The prevailing theoretical approach in this field holds that the ventral object processing stream has a modular organization, in which visual perception is carried out in posterior regions and visual memory is carried out, independently, in the anterior temporal…

Case studies of extremely gifted individuals often reveal unique patterns of intellectual precocity and associated abnormalities in development and behavior. This article begins with a review of current neurophysiological and neuroanatomical findings related to the gifted population. The bulk of scientific inquiries provide evidence of unique…

This article addresses issues in embodied sentence processing from a "cognitive neural systems" approach that combines analysis of the behavior in question, analysis of the known neurophysiological bases of this behavior, and the synthesis of a neuro-computational model of embodied sentence processing that can be applied to and tested in the…

A critical issue for Ericsson et al.'s proposal is the development of a fully adequate description of neurophysiological substrates for deliberate practice. Ericsson et al. do provide two substantial subsections on biological substrates--namely, their subsections, "Acquisition of superior power, control, and speed of motor activities" and…

Down Syndrome (DS) caused by trisomy 21 is characterized by a variety of phenotypes and involves multiple organs. Sequencing of human chromosome 21 (HSA21) and subsequently of its orthologues on mouse chromosome 16 have created an unprecedented opportunity to explore the complex relationship between various DS phenotypes and the extra copy of…

Stimulation paradigms that induce perforant path long-term potentiation (LTP) initiate phosphorylation of ERK1/2 and induce expression of a variety of immediate early genes (IEGs). These events are thought to be critical components of the mechanism for establishing the changes in synaptic efficacy that endure for hours or longer. Here we show that…

In many regions of the brain, including the mammalian cortex, the strength of synaptic transmission can be bidirectionally regulated by cortical activity (synaptic plasticity). One line of evidence indicates that long-term synaptic potentiation (LTP) and long-term synaptic depression (LTD), correlate with the phosphorylation/dephosphorylation of…

Describes recent neurophysical theories regarding the different functions of the brain's left hemisphere (linear, time-oriented, rational, and analytic) and right hemisphere (intuitive, artistic, and creative) and discusses their implications for management science. (Available from Office of Publications, Graduate School of Business…

Relationships between motor and speech development and between speech and cognitive development are considered. Discussion first focuses on issues of motility, speech, and cognition. Brief descriptions of Steiner's postulated six additional senses--of warmth, movement, life, speech or word, thought, and ego--are provided as preparation to the…

A new method generates specific predictions concerning the expected frequencies of aphasia after unilateral injury to the brain in the left- and right-handed. These predictions are then compared with the observed data for all known studies between 1935 and 1973 to derive the best-fitting model of hemispheric speech lateralization in the left- and…

Acetylcholine release in sensory neocortex contributes to higher-order sensory function, in part by activating nicotinic acetylcholine receptors (nAChRs). Molecular studies have revealed a bewildering array of nAChR subtypes and cellular actions; however, there is some consensus emerging about the major nAChR subtypes and their functions in…

This article describes a simulation designed to illustrate the electrical behavior of excitable membranes. The simulator, based on the Hodgkin-Huxley Model of the Membrane, is a simple devie that allows the student to see the consequences of changing equilibrium potentials and conductances. Numerous illustrations are included. (Author/MA)

The goal of this work is to extend the theoretical understanding of the relationship between hippocampal spatial and memory functions to the level of neurophysiological mechanisms underlying spatial navigation and episodic memory retrieval. The proposed unifying theory describes both phenomena within a unique framework, as based on one and the…