Diagnostic accuracy studies often evaluate diagnostic tests at several threshold values, aiming to make recommendations on optimal thresholds for use in practice. Methods for meta-analysis of full receiver operating characteristic (ROC) curves have been proposed but still have deficiencies. We recently proposed a parametric approach that is based…

Diagnostic test accuracy studies frequently report on sensitivities and specificities for more than one threshold of the diagnostic test under study. Although it is obvious that the information from all thresholds should be used for a meta-analysis, in practice, frequently, only a single pair of sensitivity and specificity is selected. To overcome…

Systematic reviews and meta-analyses are the cornerstones of evidence-based medicine and inform treatment, diagnosis, or prevention of individual patients as well as policy decisions in health care. Statistical methods for the meta-analysis of intervention studies are well established today. Meta-analysis for diagnostic accuracy trials has also…