Autistic adults face elevated risks for depression and unemployment, yet a systematic review of studies on the intersection of depression and employment in autism is needed to inform research and clinical efforts. The present review synthesizes findings from studies that (1) measure both depression and employment in autistic adults, and (2) empirically test associations between these constructs. Results support other work indicating elevated prevalence rates of depression and unemployment in autism with new information on the complex associations between constructs. Insights from the present review were used to (1) discuss associations between depression and employment in autism, (2) identify current challenges to understanding the intersection of depression and employment in autism, (3) propose future lines of research, and (4) suggest clinical applications for providers (e.g., mental health clinicians, vocational rehabilitation practitioners) working with autistic adults.