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Peer reviewed
Direct linkAmmassari-Teule, Martine – Learning & Memory, 2020
Largely inspired from clinical concepts like brain reserve, cognitive reserve, and neural compensation, here we review data showing how neural circuits reorganize in presymptomatic and early symptomatic hAPP mice to maintain memory intact. By informing on molecular alterations and compensatory adaptations which take place in the brain before mice…
Descriptors: Brain, Cognitive Processes, Neurological Organization, Animals
Smith, Elizabeth; Hedge, Craig; Jarrold, Christopher – American Journal on Intellectual and Developmental Disabilities, 2019
Executive function (EF) decline is a consistent early sign of Alzheimer's disease (AD) among adults with Down syndrome (DS), which means that baseline measures of EF for individuals with DS are vital to allow detection of meaningful decline. We developed a framework to extract measures of three core components of EF (memory updating, inhibitory,…
Descriptors: Executive Function, Down Syndrome, Identification, Clinical Diagnosis
Pistono, Aurélie; Jucla, M.; Bézy, C.; Lemesle, B.; Le Men, J.; Pariente, J. – International Journal of Language & Communication Disorders, 2019
Background: Alzheimer's disease is characterized by macrolinguistic changes. This decline is often analyzed with quantitative scales. Aims: To analyze discourse production in early Alzheimer's disease (AD) and to identify qualitative markers of macrolinguistic decline. Methods & Procedures: We analyzed macrolinguistic features of a clinical…
Descriptors: Alzheimers Disease, Correlation, Discourse Analysis, Identification
Plancher, G.; Tirard, A.; Gyselinck, V.; Nicolas, S.; Piolino, P. – Neuropsychologia, 2012
Most neuropsychological assessments of episodic memory bear little similarity to the events that patients actually experience as memories in daily life. The first aim of this study was to use a virtual environment to characterize episodic memory profiles in an ecological fashion, which includes memory for central and perceptual details,…
Descriptors: Computer Simulation, Alzheimers Disease, Diseases, Identification
Fortinsky, Richard H.; Zlateva, Ianita; Delaney, Colleen; Kleppinger, Alison – Gerontologist, 2010
Purpose: This article explores primary care physicians' (PCPs) self-reported approaches and barriers to management of patients with dementia, with a focus on comparisons in dementia care practices between PCPs in 2 states. Design and Methods: In this cross-sectional study, questionnaires were mailed to 600 randomly selected licensed PCPs in…
Descriptors: Physicians, Alzheimers Disease, Identification, Patients
Chang, Yu-Ling; Bondi, Mark W.; Fennema-Notestine, Christine; McEvoy, Linda K.; Hagler, Donald J., Jr.; Jacobson, Mark W.; Dale, Anders M. – Neuropsychologia, 2010
Understanding the underlying qualitative features of memory deficits in mild cognitive impairment (MCI) can provide critical information for early detection of Alzheimer's disease (AD). This study sought to investigate the utility of both learning and retention measures in (a) the diagnosis of MCI, (b) predicting progression to AD, and (c)…
Descriptors: Control Groups, Alzheimers Disease, Correlation, Verbal Learning
