Promoting quality of life (QOL) has become a goal of support services for people with disabilities and a key intervention outcome. The aim of this study was to examine the psychometric properties of the adapted Spanish version of the Cerebral Palsy Quality of Life Questionnaire (CP QOL) for children and adolescents, in its self-report and primary caregiver-report versions. The Spanish versions were translated and adapted following the guidelines for cross-cultural adaptation. Eighty-two children and adolescents with CP and 304 primary caregivers completed the final Spanish versions of the CP QOL, the KIDSCREEN-27, and instruments to measure functioning. Exploratory Factor Analysis yielded a distinguishable domain structure similar to the original English version. Cronbach's alpha ranged between 0.75 and 0.91 for primary caregiver reports and between 0.81 and 0.91 for child/teen self-reports. Moderate and weak correlations were observed between the CP QOL and the generic measure of QOL and functioning. This study provides a valid instrument to assess the QOL of children and adolescents with CP in the Spanish context.