Few studies provide specific rates of marital divorce or separation in association with a history of infidelity. Research based primarily from clinical or help-seeking populations suggests that most couples who have experienced infidelity do not divorce within the time frames assessed. Using self-reported history of extramarital sex (EMS), divorce, and separation data from 16,090 individuals assessed between 1991 and 2008 as part of the General Social Survey (GSS), the authors found that, relative to married (and never divorced) individuals, a history of EMS raised the likelihood of being currently divorced but remarried (odds ratio [OR] = 2.6), divorced and not remarried (OR = 4.1), and separated (OR = 5.8). While there are interpretive limitations, the data from the GSS suggest that more than half of men and women who engage in EMS also separate or divorce from their spouse. Results are discussed in terms of methodological differences among studies as well as clinical implications. (Contains 4 notes and 3 tables.)