The performance history of 277 students in clothing and textile from two tertiary institutions in southern Nigeria was studied by artificial neural networks (ANN) and analysis of variance (ANOVA) in terms of institution, gender, ordinary level (O-level) qualification, marital status, and age. The study was guided by five research questions and five hypotheses tested at the 0.05 level of significance. ANOVA is utilised to identify significant differences in academic performance among groups formed by the aforementioned factors. The most significant factors identified through ANOVA are used as input features for the ANN model. The dataset for the ANN model development was randomly distributed into three groups training (80%), validation (10%), and testing (10%). Hypothesis testing indicates significant differences in students' academic performance between institutions and based on O-level qualifications. Further research can build upon these findings to enhance the quality of education in the field of clothing and textiles.