In this study, the high school and college GPAs of college students who were screened as twice-exceptional were compared to college students screened as gifted and average college students. From a sample of 32,741 college students, those screened as gifted earned significantly higher means than students screened as twice-exceptional (2e) and the general college population on both high school and college GPA (p < 0.05); students screened as 2e earned high school and college GPA means higher than those from the general college population (p < 0.05). No mean college GPA differences were found between students screened as 2e with STEM majors and those with non-STEM majors GPA (p > 0.05), but STEM majors had higher high school mean GPAs than those with non-STEM majors (p < 0.001). Additionally, 2e students screened as having a reading learning disability (LD) yielded higher mean high school and college GPAs than 2e students screened as having a math LD (p < 0.001). Implications for advising are discussed.