This article describes methods for operationalizing the concept of interdisciplinarity. The methods respond to the characteristics of giftedness and strategies of differentiation. In selecting and using an interdisciplinary strategy, educators need to consider the compatibility of the purpose or objective of interdisciplinarity to the curriculum and/or instructional objective or goal, readiness of learners, availability of resources, and allocation of time for teaching and learning. Moreover, teachers and students need to value open-ended learning and the value of inquiry.