This article investigates how animacy in interaction with the syntactic function of a referent's antecedent determines the interpretation of different types of pronouns and demonstratives in German and Italian. The results of a sentence continuation task conducted in both languages show that Italian null pronouns and German p-pronouns have a strong tendency to refer to a preceding subject, but only if its referent is animate. With inanimate subjects, both forms tend to refer to the animate referent in object position, showing that animacy enhances a referent's accessibility more than the syntactic function of its previous mention. Demonstratives in German and Italian generally tend to refer to object antecedents, a tendency that is also influenced by the animacy of the referent, especially in German. The cross-linguistic comparison reveals that the effect of animacy is overall stronger in German than in Italian, suggesting that across languages, different forms may show a different sensitivity to syntactic function and animacy.