This article introduces neurodevelopmental and clinical considerations for treating adolescents with co-occurring attention deficit hyperactivity disorder (ADHD) and adolescent substance use (ASU) in outpatient settings. We first describe neurobiological impairments common to ADHD and ASU, including comorbidity with conduct disorder, that evoke a…

The congenital disorders of glycosylation (CDG) are a rapidly growing group of inborn errors of metabolism that result from defects in the synthesis of glycans. Glycosylation is a major post-translational protein modification and an estimated 2% of the human genome encodes proteins for glycosylation. The molecular bases for the current 60…

Aim: Worster-Drought syndrome (WDS), or congenital suprabulbar paresis, is a permanent movement disorder of the bulbar muscles causing persistent difficulties with swallowing, feeding, speech, and saliva control owing to a non-progressive disturbance in early brain development. As such, it falls within the cerebral palsies. The aim of this study…

Purpose: The aims of this paper are to: briefly review the long-term or late effects of cancer diagnosis and treatment on children and youth; examine the implications of these effects on the educational needs of the child or youth; explore the implications of childhood cancer survivorship on the school, particularly for female students. Over the…

College age students are in the midst of important psychosocial and neurobiological changes. The developmental fluidity of this period of life compels caution in diagnosing and treating depressive episodes, especially in discriminating between bipolar and non-bipolar depression. Treating college age students with depression requires adherence to…

This review of the research literature finds that consistent threads are emerging from reading and imaging research that reading disability is a heterogeneous condition. It reports that when disabled readers with oral language deficits are separated from those with no oral language deficits, modern imaging studies reveal differences in brain…

Research prospects and priorities in autism are discussed with respect to: (1) diagnosis, classification, and epidemiology; (2) clinical research; (3) neuropsychological research; (4) genetics; (5) structural and functional brain imaging; (6) postmortem studies; (7) other biological research; and (8) treatment research. Application of research…

This paper explores the historical origins of attention deficit disorder/attention deficit hyperactivity disorder (ADD/ADHD) as a neurological disorder, current neurological and genetic research concerning the etiology of ADD/ADHD, and implications for diagnosis and treatment. First, ADD/ADHD is defined and then the origins of ADD/ADHD as a…

The article discusses neuropsychological and treatment aspects of brain behavior disorders in children from the standpoint of terms such as minimal brain dysfunction, learning disabilities, hyperactivity, and hyperkinetic syndrome. (Author/DLS)

This review presents the most recent research concerning neuroimaging in developmental disabilities. Changes in structure and activation have been found in children with ADHD and learning disabilities, following intervention. For the children with learning disabilities changes in activation have been found following intensive behavioral and…

This fact sheet uses a question-and-answer format to summarize what is known about Prader-Willi Syndrome (PWS), a complex genetic disorder resulting in short stature, mental retardation or learning disabilities, incomplete sexual development, characteristic behavior problems, low muscle tone, and an involuntary urge to eat constantly, which…

This monograph describes community rehabilitation services available to persons with traumatic brain injury in Israel. Following a foreword by Leonard Diller which cites the incidence of traumatic brain injury and notes existing intervention models, an introductory chapter by Shlomo Katz and Victor Florian provides a historical survey of the…

This report on the state of the science in autism contains responses to questions posed by the National Institutes of Health (NIH) and recommendations concerning diagnosis, epidemiology, pathophysiology, communication/social/emotional development, medical intervention, social and behavioral intervention, and biostatistics. General recommendations…

The paper presents a discussion of human mental processes as they relate to learning disabilities. Pathognomonic symptoms associated with disturbances to brain areas or functional systems are discussed, as well as treatment procedures. This brain behavior relationship is offered as a basis for a classification system that is seen to more clearly…

This report is the result of three expert panels (on language and language impairments, balance and balance disorders, and voice and voice disorders) which met in 1994 and 1995 and reported research accomplishments, federal program goals, and research opportunities to the National Deafness and Other Communication Disorders Advisory Board. For…