Infants' preference for vowelharmony (VH, a phonotactic constraint that requires vowels in a word to be featurally similar) is thought to be language-specific: Monolingual infants learning VH languages show a listening preference for VH patterns by 6 months of age, while those learning non-VH languages do not (Gonzalez-Gomez et al., 2019; Van Kampen et al., 2008). We investigated sensitivity to advanced tongue root (ATR) harmony in Akan (Kwa, Niger-Congo) in 40 six-month-old multilingual infants (21 girls) in Ghana, West Africa (an understudied population), all learning Akan, Ghanaian English, and most of them several other understudied African languages (e.g., Ga, Ewe). We hypothesized that infants learning both ATR harmony and nonharmony languages would demonstrate sensitivity to ATR harmony. Using the central fixation procedure, infants were presented with disyllabic nonwords that were either harmonic (e.g., puti) or nonharmonic (e.g., pet[open-mid back rounded vowel]) based on their ATR features. Infants demonstrated sensitivity to ATR harmony with a familiarity preference, listening longer to harmonic syllable sequences than nonharmonic ones. The relative amount of exposure to (an) ATR harmony language(s) did not modulate the preference. These results shed light on our understanding of early multilingualism: they suggest that early sensitivity to VH in multilinguals may be similar to monolingual infants learning other types of VH, irrespective of simultaneous experience with non-VH languages. We conclude with reflections on studying infant language acquisition in multilingual Africa.