To collect reliable statistical data on domestic violence in Curaçao, we conducted a large-scale quantitative study (n = 816). To meet with the special needs of the population and topic, we designed a tailored mixed-mode survey to assess the prevalence of domestic violence in Curaçao and its health consequences. Great care was taken to reduce selective nonresponse and stimulate open and honest responses. We describe how we implemented and tailored a mixed-mode survey and report on its consequences for response and data quality.