In the 2021-22 school year, public schools identified roughly 1.2 million students experiencing homelessness, according to recent U.S. Department of Education data (NCHE, 2023). The high mobility that may occur because of homelessness creates challenges that impact students academically. Addressing these challenges requires cross-sector collaboration with the homelessness response system to provide stable housing for students and their families. This brief provides State Coordinators for Homeless Education, local homeless education liaisons, and staff of homeless assistance programs, as well as members of Continuums of Care, an overview of the statutory requirements that establish a framework for collaboration between the education and homelessness response systems to support the academic and non-academic needs of students experiencing homelessness. The brief also provides best practices on collaboration between schools and homeless service providers, including an example in practice spotlighting cross-sector collaboration in Central Florida.