This Research-to-Impact brief is the eighth in a series from Voices of Youth Count. Voices of Youth Count is a national research and policy initiative designed to fill critical gaps in the nation's knowledge about unaccompanied homelessness among youth and young adults ages 13 to 25. Voices of Youth Count research estimated that nearly 4.2 million youth and young adults in America experience some form of homelessness during a 12-month period. This brief summarizes research-based evidence on the effectiveness of interventions intended to prevent youth homelessness, reduce its duration and effects, and promote sustainable improvements in youth well-being. Accordingly, Voices of Youth screened nearly 4,000 studies, focusing on studies that evaluate the effectiveness of youth interventions. The screening process ultimately identified 62 studies that involved youth homelessness and evaluated the impacts of 51 programs. In this brief, critical evidence gaps are revealed that can prompt targeted investments in research and evaluation.