"La gran Cenobia" deals with the war between Queen Zenobia of Palmyra and the Emperor Aurelian. Calderon de la Barca draws most of his information from historical sources; the dramatist, however, changes history and adapts it to his own dramatic purpose. The theme of Fortune gives unity to the play. Aureliano is portrayed as a tyrant who, to prove his independence from Fortune, behaves tyrannically, causing his eventual downfall. Cenobia believes that Fortune controls her life, but does not acknowledge that her own actions contribute to her misfortune. The analysis concludes that Fortune, as depicted in this play, is not an omnipotent and blind force, but what one has forged with his or her own actions coupled with the actions of others and circumstance. (Contains 13 notes.)