Although HIV rates are statistically stable, meaning the number of new acquisitions has remained relatively flat, the impact of the epidemic is uneven. Black women between the ages of 13 and 34 are more likely to acquire HIV, suggesting intervention during college is an ideal HIV mitigation strategy. Moreover, far too few Black women who could benefit from biomedical interventions have them or know about them. In this piece, I explore the current landscape and context of HIV and the college environment for Black women, revealing the social, cultural, and epistemic need to restory and better nuance the HIV crisis. I elucidate how and why the college context is a particularly vital space for HIV-related health equity and the possibilities for transformation through teaching, research, practice, and policies around HIV and Black women.