College piano teaching with multimedia technology has the characteristics of more intuitive teaching content and more convenient teaching methods. It has a significant auxiliary role in improving the teaching effect and cultivating personalized music talents. Therefore, educational circles and music festivals at home and abroad have also conducted corresponding research on the application of multimedia technology. On the basis of investigating the current situation of piano education at home and abroad, this article summarizes the background significance of the development and application of multimedia technology, and points out the shortcomings of existing multimedia applications. This article analyzes the possible problems in the application of piano education in colleges and universities. Finally, it discusses the innovative application and development prospects of multimedia technology in piano teaching in colleges and universities, and analyzes the key problems that need to be solved in the implementation of multimedia technology in piano teaching.