More students with disabilities are attending university than ever before. Many universities are adopting Universal Design for Learning (UDL) as a framework for accessible course design and delivery. Audio podcasting is a strategy well-aligned with all three principles of UDL, providing students with options for engagement, representation, and expression. The current systematic review explored the use of audio podcasting in higher education and its impact on teaching and learning. A total of 17 studies were examined based on the three principles of UDL. Findings suggest that although there is limited evidence of its impact on learning, students and educators find podcasting to be a unique way to engage with content.