With the relatively recent technological advances, Multi-User Virtual Environments (MUVEs) have become a promising venue for education; however, little is known about their effective implementation in the classroom. This paper addresses this gap by investigating the creation, implementation, product and evaluation of an instructional design using the MUVE platform Second Life (SL) as a major component of an undergraduate course for pre-service teachers. The intervention was implemented in an undergraduate, general education course on Adolescent Psychology over the course of a semester. It was developed by the research team together with the course instructor. Each class, the students had a lecture about a specific topic of the course and spent the second half of the class (1-1.5 hours) engaging in activities in Second Life. The class was held in a computer lab. Students (n=30) were also asked to blog in response to weekly prompts. The current intervention is a promising tool in advancing instructional approaches in technology-enhanced learning.