Describes the method, present status, and application of positron emission tomography (PET), an analytical imaging technique for "in vivo" measurements of the anatomical distribution and rates of specific biochemical reactions. Measurements and image dynamic biochemistry link basic and clinical neurosciences with clinical findings…

Discusses the role of dogs in research, considering their use in studies related to: behavior; aging; anesthesia; gastrointestinal surgery; the brain; organ transplants; radiobiology; trauma and shock; arterial diseases; hemophelia; ophthalmology; diabetes; nutrition; cancer; lupus; cyclic neutropenia; thyroiditis; hepatitis; skeletal system,…

Discusses major uses of rats as experimental animals for studying health concerns, pointing out that their size, gestation, and histocompatibility make them useful in various studies. Topic areas addressed include aging, autoimmune disease, genetics, cancer, diabetes, hypertension, infection, reproduction, and behavior. (DH)

Discusses recent advances in the understanding of the photoreceptor function. Phototransduction, photoreceptor syncitium, and the signal at the synapse are among the topic areas addressed. (DH)

Traces the history of the antivivisection movement, examining issues related to the use of animals in studying the cause of rabies. Also discusses issues related to the current controversy over animal experimentation. (JN)

Provided are abstracts of papers presented at the annual American Physiological Society meeting and International Conference on Hydrogen Ion Transport in Epithelia. Papers are grouped by such topic areas as lung fluid balance, renal cardiovascular integration, smooth muscle physiology, neuroendocrines (pituitary), exercise physiology, mechanics of…

Reviews the pros and cons of using animals or alternatives in scientific research. Such alternatives (as indicated in congressional bill HR 556) include mathematical models, isolated organs, tissue and cell cultures, computer simulations, mechanical models, and "lower" organisms among others. (SK)

Highlights the background, career, and major accomplishments of Robert Allan Weinberg, professor of Biology at the Massachusetts Institute of Technology. His accomplishments and research interests focus on oncogenes, genes capable of causing cancer. The discovery of these genes has revealed the central mechanism of cancer. (Author/JN)

Describes the research efforts of scientists involved in discovering chemical transmission of the nerve impulse. The work includes that of J.N. Langley, George Oliver, Edward A. Schafer, Reid Hunt, Henry Dale, Henry Wellcome, Otto Loewi, and others. The discovery and the importance of both acetylcholine and adrenaline are also discussed. (84…

Traces the history of using mice for medical research and discusses the benefits of using these animals for studies in bacteriology, virology, genetics (considering X-linked genetic homologies between mice and humans), molecular biology, immunology, hematology, immune response disorders, oncology, radiobiology, pharmacology, behavior genetics,…

Summarizes recent research on hormonal control of fetal growth, presenting data obtained using a new method for studying the area. Effects of endocrine ablations and congenital deficiencies, studies of hormone/receptor levels, in-vitro techniques, hormones implicated in promoting fetal growth, problems with existing methodologies, and growth of…

Examines the extent to which issues related to animal experimentation are in conflict and proposes choices that might least comprise them. These issues include animal well-being, human well-being, self-interest of science, scientific validity and responsibility, progress in biomedical and behavioral science, and the future quality of medical care.…

In wake of a number of highly publicized incidents of research fraud at some of the nation's most prestigious medical schools, the Association of American Medical Colleges (AAMC) has developed guidelines for coping with dishonesty in science. Highlights of these guidelines are reviewed. (Author/JN)

Provides abstracts of contributed and invited papers presented at the 32nd Annual Fall Meeting of the American Physiological Society, held in Cincinnati, Ohio, October 11-16, 1981. (CS)

Described is a new approach to investigative physiology based on computerized transaxial tomography, in which visualization and measurement of the internal structure of the cardiopulmonary system is possible without postmortem, biopsy, or vivisection procedures. Examples are given for application of the Dynamic Spatial Reconstructor (DSR). (CS)