College and career pathways represent a significant national education reform movement supported by federal, state, and philanthropic funding. High school pathways combine career and technical education with rigorous academics, work-based learning, and integrated student supports to provide equitable access to postsecondary opportunities. Strong research evidence supports this specific combination of interventions as a means to address the opportunity gap and the underlying causes of disparate high school outcomes. A consortium of ten research and policy organizations, facilitated by UC Berkeley's College and Career Academy Support Network (CCASN) collaborated from 2016 to 2019 to conduct four symposia. The symposia were intended to examine the available research on college and career pathways in order to identify high leverage gaps and opportunities with the aims of: (1) prioritizing a research agenda that could impact policy and practice; and (2) promoting collaboration among researchers. This report is from the fourth and final symposium, "Aligning College and Career Pathway Systems for Equity." Participants identified the high priority problems of system alignment affecting equitable pathway development, and the specific research questions that need to be answered in order to guide policy and practice. [For the third symposium, see ED597770.]