Foodborne illness and food safety risks pose health threats to everyone, including international college students who live in the United States and encounter new or unfamiliar foods. This study assessed the prevalence of self-reported foodborne illness among international college students by cultural regions and length of time in the United States. Eight land grant institutions were contacted for participation. Directors of international students and scholars (ISS) programs at participating institutions agreed to forward a link containing an online survey to international students enrolled at their respective universities. Cross-tabulations were used to determine percentages of self-reported foodborne illness and other food safety risks among respondents by cultural regions and length of time lived in the U.S. Results indicated that 28.6% respondents self-reported they have been sick due to foodborne illness within the past year in the U.S., 10.1% have sought medical attention, and 3.2% have reported a suspected foodborne illness, 30.8% and 29.8%, respectively, have avoided particular restaurants or foods for fear of foodborne illness. Foodborne illness may be a concern among international college students in the U.S. International students in cultural regions with high percentages of self-reported foodborne illness such as Latin America, Africa, Ex-Communist, Catholic Europe, Confucian, and South Asia were more at risk of foodborne illness than other population groups. The self-reported percentage of foodborne illness was higher among international students who had lived in the U.S. for 3 years or more, than those who had lived in the U.S. for 2 years or less. Health educators could focus efforts on reaching international college students with appropriate food safety messages during their early stages of acculturation to mitigate risks of foodborne illness. (Contains 4 tables.)