The aim of this study was to develop molecular genetics inquiry programs using the "eyes absent" gene of "Drosophila melanogaster." The program was composed of various molecular genetics experiments, including mutation observation, cross-breeding, searching for genetic information in web databases, gDNA extraction, and PCR.…

Most undergraduate students do not have practical experience working with model organisms despite having theoretical knowledge of their importance. This practical was developed to offer students experience working with three species of nematode, including "Caenorhabditis elegans." In the first task, students prepare slides of three…

Genetics is an important basic course in the field of life science, and the cultivation of students' practical ability should be emphasized in the experimental teaching of genetics. How to let students have more time to participate in the experimental practice within the limited class hours? Our genetics experimental teaching team has developed…

Bridging organic and inorganic chemistry as well as molecular biology, this undergraduate experiment deals with the synthesis of ligands for metal complexes that can cleave DNA. Students gain theoretical and experimental expertise about metal--DNA interactions and the mechanisms behind DNA cleavage. This experiment lays a basis for the…

With the increasing importance in the application of the molecular biological detection technology in the field of food safety, strengthening education in molecular biology experimental techniques is more necessary for the culture of the students in food quality and safety major. However, molecular biology experiments are not always in curricula…

Homologous recombination, a central concept in biology, is defined as the exchange of DNA strands between two similar or identical nucleotide sequences. Unfortunately, undergraduate students majoring in biotechnology often experience difficulties in understanding the molecular basis of homologous recombination. In this study, we developed and…

This study examines how two kinds of authentic research experiences related to smoking behavior--genotyping human DNA (wet lab) and using a database to test hypotheses about factors that affect smoking behavior (dry lab)--influence students' perceptions and understanding of scientific research and related science concepts. The study used pre and…

Carl Erich Correns (1864-1933) is remembered in the annals of science as one of the three botanists who re-discovered Mendel's laws. He can also, however, be regarded as one of the founding figures of classical genetics in Germany. Between 1894 and 1899 he carried out the crossing experiments with corn and peas that led to the re-statement of…

This historical narrative describes the foundation of education as established by J. A. Comenius (1592-1670). It explores the transfer of Comenius' tenets, utilized and modified through the years, up to their impact upon the ground-breaking experiments of G. Mendel (1822-1884), "the father of genetics". It explores the questions of…

Science textbooks and classes mostly emphasize what are considered by today's standards the "right" or "correct" interpretations of particular phenomena or processes. When "incorrect" ideas of the past are mentioned at all, it is simply to point out their errors, with little attention as to why the ideas were put…

Recent studies indicated that the aberrant gene expression of peroxiredoxin-6 (prdx6) was found in various kinds of cancers. Because of its biochemical function and gene expression pattern in cancer cells, the association between genetic polymorphism of Prdx6 and cancer onset is interesting. In this report, we have developed and implemented a…

It has been noted that undergraduate project-based laboratories lead to increased interest in scientific research and student understanding of biological concepts. We created a novel, inquiry-based, multiweek genetics research project studying Ptpmeg, for the Introductory Biology Laboratory course at Brandeis University. Ptpmeg is a protein…

We selected diabetes mellitus for this laboratory exercise to provide students with an explicit model for scientific research concerning the association between the R230C polymorphism and susceptibility to type 2 diabetes mellitus, which is highly prevalent in the Mexican population. We used a collaborative project-based learning to engage…

Mating between closely related individuals often causes reduced fitness, which is termed "inbreeding depression". Inbreeding is, therefore, a threat towards the persistence of animal and plant populations. Here we present methods and results from a practical for high-school and first-year university students and discuss learning outcomes…

Biomedical research has produced vast amounts of new information in the last decade but has been slow to find its use in clinical applications. Data from disparate sources such as genetic studies and summary data from published literature have been amassed, but there is a significant gap, primarily due to a lack of normative methods, in combining…