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Direct linkLi, Kuokuo; Fang, Zhenghuan; Zhao, Guihu; Li, Bin; Chen, Chao; Xia, Lu; Wang, Lin; Luo, Tengfei; Wang, Xiaomeng; Wang, Zheng; Zhang, Yi; Jiang, Yi; Pan, Qian; Hu, Zhengmao; Guo, Hui; Tang, Beisha; Liu, Chunyu; Sun, Zhongsheng; Xia, Kun; Li, Jinchen – Journal of Autism and Developmental Disorders, 2022
The clinical similarity among different neuropsychiatric disorders (NPDs) suggested a shared genetic basis. We catalogued 23,109 coding de novo mutations (DNMs) from 6511 patients with autism spectrum disorder (ASD), 4,293 undiagnosed developmental disorder (UDD), 933 epileptic encephalopathy (EE), 1022 intellectual disability (ID), 1094…
Descriptors: Mental Disorders, Genetics, Patients, Autism
Download full textNiepotter, Paige; Gopalan, Chaya – HAPS Educator, 2019
Mitochondrial dysfunction has been linked to many psychiatric disorders. Ketogenic diets have been shown to reduce mitochondrial dysfunction and thus may be helpful to patients who suffer from these disorders. In this article, we review the effects of a ketogenic diet in patients with psychiatric disorders such as autism, depression, anxiety, and…
Descriptors: Depression (Psychology), Anxiety, Mental Disorders, Genetics
Bakken, Trine Lise; Hoidal, Siv Helene – International Journal of Developmental Disabilities, 2019
Background: Mental health services for patients intellectual disabilities (ID) and additional mental illnesses are only sparsely studied. Objective: The objective was to describe a representative sample of patients with ID in a specialized psychiatric department. Methods: Data were collected from case files in a 7-year period. Of 143 invited…
Descriptors: Patients, Psychiatric Hospitals, Behavior Disorders, Posttraumatic Stress Disorder
Johnson, Sarah L. M.; Wang, Lei; Alpert, Kathryn I.; Greenstein, Deanna; Clasen, Liv; Lalonde, Francois; Miller, Rachel; Rapoport, Judith; Gogtay, Nitin – Journal of the American Academy of Child & Adolescent Psychiatry, 2013
Objective: The hippocampus has been implicated in the pathogenesis of schizophrenia, and hippocampal volume deficits have been a consistently reported abnormality, but the subregional specificity of the deficits remains unknown. The authors explored the nature and developmental trajectory of subregional shape abnormalities of the hippocampus in…
Descriptors: Genetics, Children, Pathology, Attention Deficit Disorders
Nieto, Rebeca Garcia; Castellanos, F. Xavier – Journal of Clinical Child and Adolescent Psychology, 2011
Despite the nosological distinction between bipolar disorder and schizophrenia, there is increasing evidence that these conditions share phenomenological characteristics. To examine the similarities in their patterns of cognitive impairment, we conducted a meta-analysis from 12 studies of Early Onset Schizophrenia (EOS) and 12 studies of Pediatric…
Descriptors: Schizophrenia, Verbal Learning, Patients, Cognitive Processes
Mazhari, Shahrzad; Price, Greg; Dragovic, Milan; Waters, Flavie A.; Clissa, Peter; Jablensky, Assen – Brain and Cognition, 2011
Poor performance on the antisaccade task has been proposed as a candidate endophenotype in schizophrenia. Caveats to this proposal, however, include inconsistent findings in first-degree relatives of individuals with schizophrenia, and substantial heterogeneity in individuals with the disorder. In this study, we examined antisaccade performance in…
Descriptors: Schizophrenia, Patients, Statistical Analysis, Attention Deficit Disorders
van Tricht, M. J.; Nieman, D. H.; Bour, L. J.; Boeree, T.; Koelman, J. H. T. M.; de Haan, L.; Linszen, D. H. – Brain and Cognition, 2010
Abnormalities in eye tracking are consistently observed in schizophrenia patients and their relatives and have been proposed as an endophenotype of the disease. The aim of this study was to investigate the performance of patients at Ultra High Risk (UHR) for developing psychosis on a task of smooth pursuit eye movement (SPEM). Forty-six UHR…
Descriptors: Eye Movements, Schizophrenia, Patients, Human Body
Schirmbeck, Frederike; Georgi, Alexander; Strohmaier, Jana; Schmael, Christine; Boesshenz, Katja V.; Muhleisen, Thomas W.; Herms, Stefan; Hoffmann, Per; Jamra, Rami Abou; Schumacher, Johannes; Maier, Wolfgang; Propping, Peter; Nothen, Markus M.; Cichon, Sven; Rietschel, Marcella; Schulze, Thomas G. – Journal of Autism and Developmental Disorders, 2008
Whereas "Dysbindin" is considered a schizophrenia vulnerability gene, there is no consistency of findings. Phenotype refinement approaches may help to increase the genetic homogeneity and thus reconcile conflicting results. Premorbid adjustment (PMA) has been suggested to aid the phenotypic dissection. Gornick et al. ("J Autism Dev…
Descriptors: Schizophrenia, Patients, Genetics, Foreign Countries
Guerra, Seidel; Ibanez, Agustin; Martin, Migdyrai; Bobes, Maria Antonieta; Reyes, Adnelys; Mendoza, Raul; Bravo, Tania; Dominguez, Mayelin; Sosa, Mitchell Valdes – Brain and Cognition, 2009
Endophenotypes is one emerging strategy in schizophrenia research that is being used to identify the functional importance of genetically transmitted, brain-based deficits present in this disease. Currently, event-related potentials (ERPs) are timely used in this search. Several ERPs, including N400, present deficits in relation to schizophrenia.…
Descriptors: Semantics, Schizophrenia, Language Impairments, Patients
Biswas, Parthasarathy – Journal of Indian Association for Child and Adolescent Mental Health, 2008
In the last decade there has been an exponential increase in studies on neurobiological measures in childhood-onset schizophrenia (COS). There seems to be a consensus that structural changes in COS are more marked than in adolescence-onset (AdOS) or adult-onset schizophrenia (AOS). Atrophy of total brain volume is progressive throughout the course…
Descriptors: Schizophrenia, Children, Patients, Neurology
Calkins, Monica E.; Iacono, William G.; Ones, Deniz S. – Brain and Cognition, 2008
Several forms of eye movement dysfunction (EMD) are regarded as promising candidate endophenotypes of schizophrenia. Discrepancies in individual study results have led to inconsistent conclusions regarding particular aspects of EMD in relatives of schizophrenia patients. To quantitatively evaluate and compare the candidacy of smooth pursuit,…
Descriptors: Eye Movements, Schizophrenia, Patients, Genetics
Levy, Deborah L.; Bowman, Elizabeth A.; Abel, Larry; Krastoshevsky, Olga; Krause, Verena; Mendell, Nancy R. – Brain and Cognition, 2008
The "co-familiality" criterion for an endophenotype has two requirements: (1) clinically unaffected relatives as a group should show both a shift in mean performance and an increase in variance compared with controls; (2) performance scores should be heritable. Performance on the antisaccade task is one of several candidate endophenotypes for…
Descriptors: Intervals, Schizophrenia, Patients, Effect Size
Reichenberg, Abraham; Harvey, Philip D. – Psychological Bulletin, 2007
Until recently, the dominant view was that schizophrenia patients have limited, if any, neuropsychological impairments, and those that are observed are only secondary to the florid symptoms of the disorder. This view has dramatically changed. This review integrates recent evidence demonstrating the severity and profile of neuropsychological…
Descriptors: Patients, Neurology, Memory, Schizophrenia
Biswas, Parthasarathy; Malhotra, Savita; Malhotra, Anil; Gupta, Nitin – Journal of Indian Association for Child and Adolescent Mental Health, 2006
Background: Childhood onset schizophrenia (COS) is a rare disorder. Comparative data on the effect of differential age of onset on clinical profile in schizophrenia are very few. Method: Subjects with COS (n = 15), adolescence onset schizophrenia (AdOS, n = 20) and adulthood onset schizophrenia (AOS, n = 20) were compared on socio-demographic,…
Descriptors: Schizophrenia, Intelligence Quotient, Psychopathology, Children
