The aim of the current study is to estimate the graduation grade point average (GPA) at the Arab International University (AIU). The importance of this study is that it is the first of its kind in Syria, particularly under the conditions of the bitter war, which has not yet come to its end. The sample of the study consists of data collected from AIU registry system, which covers students of six faculties from both sexes over a period of 5 years, i.e., between 2014 and 2018. The variables of the study include the student's high school GPA, the source of the student's certificate, and the gender of the student (GR). MLR and ANN approaches were employed in the analytical study. The correlation coefficients and several statistical criteria were calculated to evaluate the developed models. Based on the results, it can be concluded that the male students were among the key factors affecting the output, i.e., GPA. In addition, ANN tool is more accurate when the estimation of GPA value is concerned. Further, re-evaluation of this study can be done in future particularly when the male student' trepidation disappears as stability and safety return to the country.