The COVID pandemic created significant problems for higher education worldwide, including new and exacerbated challenges related to international higher education. In this article, the authors focus on: (1) the implications for onsite and online education; (2) international student mobility and internationalization at home; (3) the impact of international mobility in education and research on climate change; (4) increasing inequalities in higher education; and (5) geopolitical tensions and knowledge security. The article concludes with actions higher education can and needs to make to overcome these crises and challenges salient to the international higher education community.